As the founder of Anera, my life is deeply tied to longevity as a business and a mission. I’m not just selling NMN; I’m living it. I test, tweak, and evolve my lifestyle around cellular health and performance daily. I recently completed my second 72-hour fast with NMN, and this one was transformative. Unlike my first fast, where I used sublingual NMN powder, this time I supported it with daily supplementation of Anera NMN + Trans-Resveratrol 24000.
Here’s why I do it and what I’ve learned so far.
My Fasting Lifestyle: How I Structure a 72-Hour Fast
Most days, I live in a rhythm of intermittent fasting: I eat twice a day, first meal around 12 PM, second at 6–7 PM. That’s it. No snacking, no grazing, no late-night eating. Just two clean, nourishing meals. It gives my digestive system the rest it needs and keeps my energy steady throughout the day.
Every once in a while, I go beyond my usual limits.
At 1 PM Friday, I started a 72-hour fast, sticking to mineral water, black coffee, matcha tea, and my Anera NMN + Trans-Resveratrol 24000 supplement. My coffee of choice is a cappuccino diluted with half hot water, and I add flaked sea salt to it for electrolytes. This combination has become part of my extended fast protocol, and it works incredibly well. My fast ended at 1 PM the following Monday. What happened in between was powerful.
This was my second time trying a 72-hour fast with NMN, and I’m thinking about doing it once a month or every other month. It has been a complete game changer for me physically, mentally, and spiritually.
What Happens During a 72-Hour Fast with NMN + Trans-Resveratrol
NMN (Nicotinamide Mononucleotide) is a direct precursor to NAD+, a molecule that powers every cell in your body and is essential for longevity, DNA repair, and mitochondrial function. Trans-Resveratrol is a potent polyphenol that acts synergistically with NMN, enhancing its effects.
When we fast, especially during extended fasts, NAD+ levels naturally rise. That’s part of why fasting is so beneficial. But supplementing with NMN + Trans-Resveratrol during a fast amplifies the benefits:
- Boosted Cellular Repair: NMN increases NAD+, which activates sirtuins — the longevity genes responsible for DNA repair and metabolic regulation. Trans-Resveratrol further activates these same pathways.
- Smoother Energy & Focus: Most people feel dips in energy during fasts. This combo helps maintain mental clarity and physical stamina by optimizing mitochondrial function.
- Enhanced Autophagy and Anti-Inflammation: Fasting promotes autophagy, the body’s process of cleaning out damaged cells. Trans-Resveratrol enhances this process while providing strong antioxidant and anti-inflammatory support.
- Synergistic Absorption: Taking NMN and Trans-Resveratrol together improves their effectiveness. Resveratrol acts like a key that unlocks NMN’s full potential by enhancing sirtuin activation.
In simple terms, it’s like fasting is the detox, NMN is the repair crew, and Trans-Resveratrol is the foreman who supercharges the entire operation.
Reflections on My First Fast: Sublingual NMN Powder Experience
During my first 72-hour fast, I chose to experiment with sublingual NMN powder instead of using the Anera NMN + Trans-Resveratrol product. I already had access to it, but I love to biohack and try different delivery methods to better understand their effects.
That experience was powerful in its own right. Sublingual delivery bypasses the digestive system and delivers NMN directly into the bloodstream, making it fast-acting and highly bioavailable. I noticed a more immediate effect in my energy levels and mental clarity, especially during the second and third day of the fast. It helped keep my focus sharp and my mindset calm as I pushed through the natural hunger waves and detox symptoms.
That fast laid the foundation for what’s now becoming a monthly or bi-monthly ritual — one that aligns perfectly with the longevity philosophy behind Anera.
What I Eat After a 72-Hour Fast with NMN
Ending a fast the right way is just as important as starting it. I’m always careful and intentional about how I start eating again. This time, like the last, I chose one of my go-to healthy aging foods to end a 72-hour fast with NMN:
Bone marrow pho broth.
It’s rich in collagen, glycine, gelatin, and essential minerals. It’s warm, easy on the gut, and supports everything from joint health to gut lining repair. After a long fast, this broth brings life back into the system gently.
I only eat two meals after the fast. The second meal comes around dinner time (6–7 PM), and it’s typically a clean, nourishing plate of steak, chicken, or salmon accompanied by fresh vegetables. That’s it simple, grounding, and deeply satisfying. And of course, I continue my NMN + Trans-Resveratrol routine to support recovery and longevity at the cellular level.
Final Thoughts: NMN + Trans-Resveratrol is My Fasting Ally
At Anera, we often say:
“If H₂O is essential for life, NMN is essential for longevity.“
And I live by that. It’s not marketing. It’s my lifestyle. I’m 48, and I’ve never felt this clear, motivated, and on the right path. NMN + Trans-Resveratrol, especially during fasting, has helped me get here.
This is just the beginning. As I keep learning, testing, and biohacking with Anera’s products, I’ll be documenting more of my journey. If you’re curious about optimizing your health or trying a fast yourself, follow along. I’m going to talk about the facts, my journey, and what happened.
We’re not just building a company.
We’re building a movement.
FAQ About 72-Hour Fasting with NMN
Q. What are the benefits of doing a 72-hour fast with NMN?
Combining NMN with a 72-hour fast enhances cellular repair, raises NAD+ levels, promotes mitochondrial function, and supports autophagy. It also improves mental clarity and physical endurance during the fast.
Q. Is it safe to take NMN during a 72-hour fast?
Yes, NMN supplementation is generally safe during fasting for healthy individuals and can enhance the benefits of fasting. Get advice from a healthcare expert before making changes to your health plan.
Q. Can I combine Trans-Resveratrol and NMN during my fast?
Absolutely. These two supplements work synergistically. Resveratrol boosts sirtuin activity, helping NMN be more effective in supporting cellular health during fasting.
Q. What’s the right time to break a 3-day fast?
The best way is to start with light, nourishing foods such as bone broth, cooked vegetables, or easily digestible proteins. Avoid heavy or processed foods to prevent digestive stress.
